Association of rs4646903 and rs1048943 CYP1A1 estrogen-metabolizing gene polymorphisms with estrogen receptor-positive breast cancer in Kenyan women

Breast cancer is the most prevalent neoplasm and second leading cause of death among females in Kenya. Estrogen its metabolites are known risk factors for breast cancer. Polymorphisms these genes susceptibility unique different populations. This study aimed to determine probable associations between estrogen-metabolizing gene variations other Kenyan women. Buffy coat samples were obtained from patients diagnosed with estrogen receptor-positive cancer, benign disease, healthy volunteers. Genotyping target polymorphisms was conducted using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis. The rs4646903 variant genotype CC associated case-control model (P=0.001); heterozygous TC (P=0.01) luminal B molecular subtype (P=0.02) showed increased odds late-stage rs1048943 GG case-benign (P=0.04), whereas CG (P=0.02). These findings imply that genotypes involved Hence, they may be explored further as potential markers disease.